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KMID : 0942820090080010035
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Journal of Korean Brain Tumor Society
2009 Volume.8 No. 1 p.35 ~ p.40
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Gamma Knife Radiosurgery for the Patients with Solitary Brain Metastasis from Lung Cancer
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Woo Hyun-Jin
Park Seong-Hyun
Hwang Sung-Kyoo
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Abstract
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Objective: Stereotactic radiosurgery has become a valued management choice for patients with brain metastases. This study was performed to assess the efficacy of GKS(Gamma knife radiosurgery) in patients with solitary brain metastasis.
Methods: From May 2005 to Dec 2007, fourteen patients(8 men and 6 women) with solitary cerebral metastatic lesion underwent GKS. The mean age was 61 years(49-74). All patients had Karnofsky performance status(KPS) score of 70 or better. The maximum diameter of the single brain metastasis was less than 3 cm. Overall survival was retrospectively analyzed by using Kaplan Meier method and variables associated with survival were evaluated by univariate analysis.
Results: The mean volume of solitary brain metastatic lesions was 6.1 cc(0.5-24.5). The median marginal dose was 20 Gy(10-23). Median follow-up period was 40 weeks. Overall median survival was 32 weeks(4-88) from GKS. Local
control rate was possible for 77% of the lesions. At the last follow-up, 12 patients(86%) were alive and 2 patients(14%)
died from systemic causes. Age(<65 years, p=0.003) and high KPS score(>80, p=0.024) were favorable prognostic
factors in univariate analysis.
Conclusion: GKS has significantly reduced the mortality from brain metastasis by effectively accomplishing local tumor control in patients with solitary brain metastasis from lung cancer.
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KEYWORD
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Lung cancer, Brain metastasis, Gamma knife radiosurgery
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